Bone Abstracts

In previous studies, discrepant effects of TSH and thyroid hormones on bone have been reported. While low TSH and high thyroxine (T4) levels increase bone turnover, a recent study suggested a positive association between triiodothyronine (T3) levels and mineral deposition in bone. No data are available on bone architecture and strength in relation to thyroid status.Aim: Using a cross-sectional design, we determined whether bone dens...

Conventional treatment of hypoparathyroidism with calcium and active vitamin D analogues causes a high renal calcium excretion and over-mineralized bone.We studied 62 patients with hypoPT randomized to 6 months of treatment with either parathyroid hormone (PTH(1-84)) 100 μg/d s.c. or similar placebo, administered as an add-on therapy. Forty-two of the patients had follow-up test performed after 2.5 years; 9 patients had continued daily PTH treatment...

Total thyroidectomy causes postsurgical hypothyroidism (HypoT). Besides HypoT, patients may also develop hypoparathyroidism (HypoPT).The aim of the study was to assess Quality of Life (QoL), muscle function, and bone indices in patients with postsurgical hypothyroidism and hypoparathyroidism (HypoT+PT) as compared to patients with postsurgical HypoT and healthy controls.Age and gender matched patients on treatment for HypoT+PT and ...